UC San Diego Jacobs School of Engineering computer science and engineering professor Russell Impagliazzo hosts a one-on-one conversation with 2021 Kyoto Prize laureate Andrew Chi-Chih Yao. Yao created new trends in computer science and made great contributions to cutting-edge research in various areas, especially in security, secure computing, and quantum computation through establishing innovative fundamental theories for computation and communication. His achievements are continuing to influence current real-world problems such as security, secure computing, and big data processing. Included is Yao's acceptance address delivered in Kyoto on the occasion of his being honored with the prestigious award.